解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CAM as a robust experimental platform to study blood vessels has ...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-014-9440-7
更新日期:2014-10-01 00:00:00
abstract::The sprouting of endothelial cells from pre-existing blood vessels represents a critical event in the angiogenesis cascade. However, only a fraction of cultured or transplanted endothelial cells form new vessels. Moreover, it is unclear whether this results from a stochastic process or instead relates to certain endot...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-014-9414-9
更新日期:2014-07-01 00:00:00
abstract:PURPOSE:There are currently no validated biomarkers predicting bevacizumab treatment outcome or toxicity. We combined biomarker data from six phase III trials of bevacizumab to assess whether genetic variation in vascular endothelial growth factor-A (VEGF-A) pathway or hypertension-related genes are associated with bev...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-014-9424-7
更新日期:2014-07-01 00:00:00
abstract::Heparan sulfate (HS), a long linear polysaccharide of alternating disaccharide residues, interacts with a wide variety of proteins, including many angiogenic factors. The involvement of HS in signaling of pro-angiogenic factors (e.g. vascular endothelial growth factor and fibroblast growth factor 2), as well as intera...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-013-9401-6
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Angiogenesis plays a pivotal role in neoplastic growth and metastasis formation. Vascular endothelial growth factor A (VEGFA) is a major player in physiological and tumour-induced angiogenesis and numerous human tumours have been show to overexpress VEGFA. Moreover increased VEGFA gene expression has been fo...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-013-9396-z
更新日期:2014-07-01 00:00:00
abstract::The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell trafficking. These functions are paramount in the establishment and development of an inflammatory response. In the past decade, an increasing number of reports has revealed that marked changes, such as lymphangiogenesis and lymphati...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-014-9416-7
更新日期:2014-04-01 00:00:00
abstract::The fusion protein tTF-NGR consists of the extracellular domain of the thrombogenic human tissue factor (truncated tissue factor, tTF) and the peptide GNGRAHA (NGR), a ligand of the surface protein CD13 (aminopeptidase N), upregulated on endothelial cells of tumor vessels. tTF-NGR preferentially activates blood coagul...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-013-9391-4
更新日期:2014-01-01 00:00:00
abstract::Antiangiogenic therapy, specially sorafenib, has become the standard of care for patients with advanced hepatocellular carcinoma (HCC), however, the improvement in survival time is not satisfactory. Previous studies have found that, in some circumstances, antiangiogenic therapy promoted tumor metastasis and the mechan...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-013-9357-6
更新日期:2013-10-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is a major angiogenic factor that activates pro-angiogenic molecules to generate new vessels. Recently, we identified a VEGF-A-induced pro-angiogenic gene, BCL-6 associated zinc finger protein (BAZF), in endothelial cells. BAZF interacts with CBF1, a transcriptional regulator ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-013-9345-x
更新日期:2013-07-01 00:00:00
abstract::Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin (ANG), the fifth member of the vertebrate-specific, secreted ribonuclease superfamily. ANG ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-012-9322-9
更新日期:2013-04-01 00:00:00
abstract::Early pregnancy is characterized by decidual adaption to the developing embryo involving angiogenesis and vascular growth. Failure of decidual vascular expansion is linked to diseases of pregnancy. Dendritic cells (DC) have been associated with vascular growth during early gestation, though it is unknown whether their...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-012-9325-6
更新日期:2013-04-01 00:00:00
abstract::Both vasculogenesis and angiogenesis occur during normal placental vascular development. Additionally, the placenta undergoes a process of vascular mimicry (pseudo-vasculogenesis) where the placental extravillous trophoblast (EVT) that invade the spiral arteries convert from an epithelial to an endothelial phenotype d...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-012-9317-6
更新日期:2013-04-01 00:00:00
abstract::VEGF-A is a crucial growth factor for blood vessel homeostasis and pathological angiogenesis. Due to alternative splicing of its pre-mRNA, VEGF-A is produced under several isoforms characterized by the combination of their C-terminal domains, which determines their respective structure, availability and affinity for c...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-012-9320-y
更新日期:2013-04-01 00:00:00
abstract::A missense mutation from arginine to tryptophan at residue 849 in the kinase domain of Tie2 (Tie2-R849W) is commonly identified in familial venous malformations. The mechanistic action of Tie2-R849W variant expression on angiogenic cascades including smooth muscle cell recruitment, however, remains elusive. To avoid c...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-012-9313-x
更新日期:2013-01-01 00:00:00
abstract::Therapeutic over-expression of vascular endothelial growth factor (VEGF) can be used to treat ischemic conditions. However, VEGF can induce either normal or aberrant angiogenesis depending on its dose in the microenvironment around each producing cell in vivo, which limits its clinical usefulness. The goal herein was ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-012-9304-y
更新日期:2013-01-01 00:00:00
abstract::Sunitinib is a potent and clinically approved tyrosine kinase inhibitor that can suppress tumour growth by inhibiting angiogenesis. However, conflicting data exist regarding the effects of this drug on the growth of metastases in preclinical models. Here we use 4T1 and RENCA tumour cells, which both form lung metastas...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-012-9291-z
更新日期:2012-12-01 00:00:00
abstract::The semaphorins and plexins comprise a family of cysteine-rich proteins implicated in control of nerve growth and development and regulation of the immune response. Our group and others have found that Semaphorin 4D (SEMA4D) and its receptor, Plexin-B1, play an important role in tumor-induced angiogenesis, with some n...
journal_title:Angiogenesis
pub_type: 杂志文章,收录出版
doi:10.1007/s10456-012-9268-y
更新日期:2012-09-01 00:00:00
abstract::During embryonic development, the lymphatic system emerges by transdifferentiation from the cardinal vein. Although lymphatic and blood vasculature share a close molecular and developmental relationship, they display distinct features and functions. However, even after terminal differentiation, transitions between blo...
journal_title:Angiogenesis
pub_type: 临床试验,杂志文章
doi:10.1007/s10456-012-9264-2
更新日期:2012-06-01 00:00:00
abstract::Angiogenesis is important for tumor growth and metastasis. CLT1 (CGLIIQKNEC), a peptide that binds to tumor interstitial spaces in the presence of fibrin-fibronectin, has structural similarity to the anti-angiogenic β-sheet peptides anastellin and anginex. This similarity is reflected in the ability of CLT1 to form co...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-011-9247-8
更新日期:2012-03-01 00:00:00
abstract::Transmembrane-4-L-six-family-1 (TM4SF1) is a tetraspanin-like membrane protein that is highly and selectively expressed by cultured endothelial cells (EC) and, in vivo, by EC lining angiogenic tumor blood vessels. TM4SF1 is necessary for the formation of unusually long (up to a 50 μm), thin (~100-300 nm wide), F-actin...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-011-9218-0
更新日期:2011-09-01 00:00:00
abstract::Endothelial progenitor cells (EPCs) play a critical role in the repair of damaged blood vessels and/or in the growth of new ones in ischemic tissues. Elevated levels of oxygen radicals, which accumulate in the ischemic tissue, could compromise the angiogenic potential of EPCs. To determine if oxidative stress alters t...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-011-9211-7
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) that is secreted by tumor cells plays a key role in angiogenesis. Matrix metalloproteinase 9 (MMP-9) is produced by inflammatory cells, such as stromal granulocytes (PMN), remodels the extracellular matrix and is known to promote angiogenesis indirectly by interactin...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-011-9207-3
更新日期:2011-09-01 00:00:00
abstract::The neurogenic areas of the brain are highly organized structures in which there is dynamic reciprocal modulation of neural stem cells (NSC) and microvascular endothelial cells (BEC) resulting in control of neural stem cell and vascular proliferation, survival and differentiation throughout the life of the individual....
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-011-9201-9
更新日期:2011-05-01 00:00:00
abstract::Anti-VEGF (vascular endothelial growth factor) therapy with the monoclonal antibody bevacizumab can cause gastrointestinal (GI) perforations. In recent years it became apparent that GI perforations also occur during treatment with antiangiogenic tyrosine kinase inhibitors (TKIs). It is of clinical importance to consid...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-010-9197-6
更新日期:2011-05-01 00:00:00
abstract::Using a fibrin-based angiogenesis model, we have established that there is no canonical mechanism used by endothelial cells (ECs) to degrade the surrounding extracellular matrix (ECM), but rather the set of proteases used is dependent on the mural cells providing the angiogenic cues. Mesenchymal stem cells (MSCs) orig...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-010-9194-9
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:EPLIN (epithelial protein lost in neoplasm) is a cytoskeletal associated protein involved in the regulation of actin dynamics and subsequently in cell motility. EPLIN expression is frequently reduced in a variety of cancer cells and tissues and this loss may account for increased invasive traits in cancer ce...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-010-9188-7
更新日期:2010-12-01 00:00:00
abstract::During the early stages of angiogenesis, following stimulation of endothelial cells by vascular endothelial growth factor (VEGF), the vascular wall is breached, allowing high molecular weight proteins to leak from the vessels to the interstitial space. This hallmark of angiogenesis results in deposition of a provision...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-010-9170-4
更新日期:2010-06-01 00:00:00
abstract::Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomical descriptions to complicated phenotypic characterizations based upon the recognition of unique cell-surface biochemical signatures. Although originally the purview of nuclear medicine, "molecular imaging" i...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-010-9166-0
更新日期:2010-06-01 00:00:00
abstract::Vascular endothelial cells undergo many molecular changes during pathological processes such as inflammation and tumour development. Tumours such as malignant lymphomas affecting bone marrow are dependent on interactions with endothelial cells for (1) site-specific homing and (2) tumour-induced angiogenesis. Modificat...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-010-9162-4
更新日期:2010-03-01 00:00:00
abstract::Therapeutic angiogenesis is a promising strategy to promote the formation of new or collateral vessels for tissue regeneration and repair. Since changes in tissue oxygen concentrations are known to stimulate numerous cell functions, these studies have focused on the oxygen microenvironment and its role on the angiogen...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-009-9152-6
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Dysregulation of the phosphatidylinositol-3-kinase (PI3K) signaling pathway is a hallmark of human cancer, occurring in a majority of tumors. Activation of this pathway is critical for transformation and also for the angiogenic switch, which is a key step for tumor progression. The objective of this study was...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-009-9154-4
更新日期:2009-01-01 00:00:00
abstract::Among the key effects of fluid shear stress on vascular endothelial cells is modulation of gene expression. Promoter sequences termed shear stress response elements (SSREs) mediate the responsiveness of endothelial genes to shear stress. While previous studies showed that shear stress responsiveness is mediated by a s...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-009-9143-7
更新日期:2009-01-01 00:00:00
abstract::Chemokine (C-C motif) receptor-2 (CCR2) regulates arteriogenesis and angiogenesis, facilitating the MCP-1-dependent recruitment of growth factor-secreting bone marrow-derived cells (BMCs). Here, we tested the hypothesis that the BMC-specific expression of CCR2 is also required for new arteriole formation via capillary...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-009-9157-1
更新日期:2009-01-01 00:00:00
abstract::Intermittent Hypoxia (IH) that develops in neovascularized solid tumours has been described to positively influence the tumour growth by modulating the behaviour of cancer cells as well as of endothelial cells. However, the molecular mechanisms regulated by IH still remain poorly understood. In this work, the effects ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-009-9156-2
更新日期:2009-01-01 00:00:00
abstract::The formation of new tubular structures from a quiescent endothelial lining is one of the hallmarks of sprouting angiogenesis. This process can be mimicked in vitro by inducing capillary-like tubular structures in a three-dimensional (3D) fibrin matrix. We aimed to analyze the differential mRNA expression in two pheno...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-007-9086-9
更新日期:2008-01-01 00:00:00
abstract::Technology has caught up with retinal diseases of neovasculature. Work with anti-cancer, anti-angiogenic agents has fueled the way for ocular therapeutics. The market size for age-related macular degeneration and diabetic retinopathy is huge. Fifteen million people in the United States alone have age-related macular d...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-007-9068-y
更新日期:2007-01-01 00:00:00
abstract::Corneal vascularisation is a potentially devastating occurrence that can cause blindness. Currently, treatments for this condition are limited. In these studies, we have investigated a novel inhibitor of angiogenesis, 12-methyl tetradecanoic acid (12-MTA), to treat corneal vascularisation in mouse models of corneal al...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-007-9063-3
更新日期:2007-01-01 00:00:00
abstract::Evidence has been gathered regarding the association between angiogenesis and inflammation in pathological situations. These two phenomena have long been coupled together in many chronic inflammatory disorders with distinct etiopathogenic origin, including psoriasis, rheumatoid arthritis, Crohn's disease, diabetes, an...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-007-9074-0
更新日期:2007-01-01 00:00:00
abstract::Human pancreatic tumors often overexpress the angiogenesis-promoting factor Interleukin 8 (IL-8), in part due to overexpression of NF-kappaB, a frequent occurrence in pancreatic adenocarcinoma. In this study, we demonstrate that reducing c-Src kinase activity, through either pharmacologic inhibition or small interferi...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-006-9038-9
更新日期:2006-01-01 00:00:00
abstract::Angiogenesis is a complex process involving coordinated steps of endothelial cell activation, proliferation, migration, tube formation and capillary sprouting with participation of intracellular signaling pathways. Regulation of angiogenesis carries tremendous potential for cancer therapy. Our earlier studies showed t...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-005-9024-7
更新日期:2005-01-01 00:00:00